perforin

perforin
n.
a protein produced by cytotoxic T-cells and natural killer cells that are in contact with virus-infected target cells. It creates pores in the target-cell membrane, which facilitates the delivery of granzymes to the cell to induce cell death (apoptosis).

The new mediacal dictionary. 2014.

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  • Perforin — 1 (pore forming protein), also known as PRF1, is a human gene.cite web | title = Entrez Gene: PRF1 perforin 1 (pore forming protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5551| accessdate = ]… …   Wikipedia

  • Perforin — 1 Vorhandene Strukturdaten …   Deutsch Wikipedia

  • perforin pathway — The cytotoxic pathway that uses perforin protein, which polymerizes to form membrane pores that help destroy cells during cell mediated cytotoxicity. Perforin is produced by cytotoxic T cells and NK cells and stored in granules that are released… …   Dictionary of microbiology

  • perforin — per·fo·rin (pûrʹfər ĭn) n. A protein in killer cells and natural killer cells that causes lysis of target cells on contact.   [perforate + in.] * * * …   Universalium

  • perforin — noun A cytolytic protein found in natural killer cells …   Wiktionary

  • perforin — A protein found in the cytoplasmic granules of both T cytotoxic lymphocytes and natural killer cells. This protein is implicated in target cell lysis by the above cells. [L. per foro, to bore, pierce, + in] * * * per·for·in (purґfə rin) a… …   Medical dictionary

  • perforin — [ pə:fərɪn] noun Biochemistry a protein, released by killer cells of the immune system, which destroys targeted cells by creating lesions like pores in their membranes. Origin 1980s: from perforate + in1 …   English new terms dictionary

  • perforin — …   Useful english dictionary

  • MACPF — Pfam box Symbol = MACPF Name = MAC/Perforin domain width = caption = Pfam= PF01823 InterPro= IPR001862 SMART= MACPF PROSITE = PDOC00251 SCOP = TCDB = 1.C.39 OPM family= OPM protein= PDB=The MACPF protein superfamily is named after a domain that… …   Wikipedia

  • Granzyme — Granzymes are serine proteases that are released by cytoplasmic granules within cytotoxic T cells and natural killer cells. Their purpose is to induce apoptosis within virus infected cells, thus destroying them.cite journal |author=Bots M, Medema …   Wikipedia

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